Seminars and thesis defences

Tuesday December 17, 2024 – 5pm – Auditoire Maisin

Audrey COMEIN – TFAR/FACM

Intracellular Persistence of Pseudomonas aeruginosa: When Bacteria Play Hide-and-Seek with Antibiotics

Promotor: Prof. Françoise Van Bambeke

Info: francoise.vanbambeke@uclouvain.be

Monday, December 16, 2024 – 1pm – Auditoire Maisin 

Prof. Roberta GUALDANI, chercheuse qualifiée FNRS, UCLouvain, IoNS, Pôle Cellulaire et Moléculaire

TRP Channel Mutations as Key Factors in Neuropathic Pain Susceptibility

Transient Receptor Potential (TRP) channels are molecular detectors of our body. They respond to changes in the cellular environment, including temperature, chemicals, stretch/pressure, osmolarity, oxidation/reduction, and pH. Several members of the TRP channel superfamily are expressed in the nerve endings of peripheral sensory neurons and play central roles in the development of acute and chronic pain.

Using a combination of molecular modeling and biophysical techniques, I am looking for recurrent TRP channel mutations in patients with severe chronic pain to understand whether there is a genetic predisposition to the development of neuropathic pain. In this context, I recently analyzed two mutations found in patients with trigeminal neuralgia [1-3], and provided key structural insights into how these mutations may cause hyperexcitability of trigeminal neurons and lead to the onset of neuropathic pain.

[1] Gualdani et al., Neurology: Genetics (2021), 7(1)

[2] Gualdani et al., PNAS (2022), 119(38), e2119630119

[3] Gualdani et al., PNAS (2024), 121(37), e2406186121

Info: laure.bindels@uclouvain.be

Thursday December 12, 2024 – 4:30pm – Auditoire Maisin

François-Xavier SIBILLE – IRSS and TFAR/CLIP

Deprescribing benzodiazepine receptor agonists in hospitalised older adults, from the description of actual practices to the development of a targeted intervention

Promotor: Prof. Marie de Saint-Hubert

Co-Promotor: Prof. Anne Spinewine

Related publications:

• Current practice in benzodiazepine receptor agonists deprescribing on acute geriatric wards: a cohort study.Sibille, François-Xavier ; Spinewine, Anne ; Zerah, Lorène ; Maljean, Laurentine ; Schoevaerdts, Didier ; de Saint Hubert, Marie. In: BMC Geriatrics, Vol. 22, no. 1 (2022), p. 88 (2022). doi:10.1186/s12877-022-02753-w. http://hdl.handle.net/2078.1/257967
• Benzodiazepine receptor agonists use and cessation among multimorbid older adults with polypharmacy: secondary analysis from the OPERAM trial François-Xavier Sibille, de Saint-Hubert Marie, Séverine Henrard, Carole Elodie Aubert, Namiko Anna Goto, Emma Jennings, Olivia Dalleur, Nicolas Rodondi, Wilma Knol, Denis O’Mahony, Matthias Schwenkglenks, Anne Spinewine. In Drugs & Aging https://doi.org/10.1007/s40266-023-01029-1

Info: anne.spinewine@uclouvain.be

Monday, December 2, 2024 – 1pm – Auditoire 51C 

Prof. Anne SPINEWINE – TFAR/CLIP

Optimising the Use of Medicines in Clinical Practice: Why and How?

Ce séminaire se déroulera en comodal : Rejoignez la réunion maintenant

Info: president-ldri@uclouvain.be

Monday November 18, 2024 - 1pm - Auditoire Maisin

Fanny DETROZ - LDRI/ADDB

Development of nanomedicines to tackle muco-obstructive lung diseases

Laudine ACKERMANS – LDRI/TFAR CLIP

Self-Perceived Knowledge, Skills, and Attitudes of Healthcare Professional Trainees in Deprescribing: a national survey

Info: mireille.alhouayek@uclouvain.be

Monday, November 4, 2024 – 1pm – Auditoire Maisin 

Prof. Benoît Guery, Médecin Chef, Service des maladies infectieuses du Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Switzerland

Dynamics of the Gut Microbiota in Clostridium difficile Infections: Eubiosis and Resilience

Info: francoise.vanbambeke@uclouvain.be

Monday, October 21, 2024 – 1pm – Auditoire Maisin 

Prof. Rita VANBEVER, ADDB

Challenges and opportunities in pulmonary drug delivery

Info: president-ldri@uclouvain.be

Monday, September 30, 2024 - 1pm - Auditoire Maisin

Jean-Michel KARKAN - Directeur du département Gestion des dépenses et des achats, Administration des finances, UCLouvain

Intérêt, obligations & procédures à suivre pour les achats de consommables et équipements

Cette séance d’information se déroulera en français.

This information session will be held in French.

Monday, September 23, 2024 - 1pm - Auditoire Maisin

Prof An GHYSELS - PhD, IBiTech - research group Biophysical Modeling for Biomedical Applications (BioMMedA), UGent

Modeling permeation of membranes: atomic-scale resolution with molecular dynamics simulations

Related publications:

• An Ghysels, Andreas Krämer, Richard M. Venable, Walter E. Teague Jr, Edward Lyman, Klaus Gawrisch & Richard W. Pastor. Permeability of membranes in the liquid ordered and liquid disordered phases. Nature Communications, volume 10, Article number: 5616 (2019).
• Samaneh Davoudi, Koen Raemdonck, Kevin Braeckmans, An Ghysels. Capric Acid and Myristic Acid Permeability Enhancers in Curved Liposome Membranes. J Chem Inf Model 2023 Nov 13;63(21):6789-6806.

Info: joseph.lorent@uclouvain.be

Monday September 16, 2024 – 4.00 pm – Salle Couvreur

Chloé Buyse - Biomedical Magnetic Resonance (REMA)

Monitoring the effect of anti-cancer drugs on extracellular pH and pO2 using magnetic resonance

Promotor: Prof. Bernard Gallez

Related publications:

• Buyse C, Joudiou N, Corbet C, Feron O, Mignion L, Flament J, Gallez B. Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI. Cancers 13(17):4278 (2021) PMID: 34503089
• Buyse C, Joudiou N, Warscotte A, Richiardone E, Mignion L, Corbet C, Gallez B. Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification. Metabolites 12(6):557 (2022) PMID: 35736489
• Buyse C, Mignion L, Joudiou N, Melloul S, Driesschaert B, Gallez B. Sensitive simultaneous measurements of oxygenation and extracellular pH by EPR using a stable monophosphonated trityl radical and lithium phthalocyanine. Free Radic Biol Med. 213:11-18 (2024) PMID: 38218552

Info: bernard.gallez@uclouvain.be