Sustainable management of the páramo ecosystem in the high Andes lacks evidence-based research on soil-vegetation interactions  and its effects on hydrological and weathering fluxes . Experimental data was collected at multiple spatial scales (from soil horizon to catchment scale) on soil properties, climate, soil hydrology and hydrochemistry. At horizon scale, differences in soil hydraulic properties between vegetation type in the upper A horizon, were mainly attributed to changes in soil structure, organic carbon and root system. The variation of these properties with depth resulted in contrasting infiltration capacity and subsurface storm flow.  At soil profile scale, vegetation type influenced infiltration and evapotranspiration along the profile; while differences on solute fluxes were restricted to the upper A horizon. These results were related to contrasting soil properties. At catchment scale, export of biogenic solutes during high flows showed that soils and wetland were connected hydrologically to the catchment outlet; while during low flows geogenic solutes dominated indicating the larger contribution of groundwater. This study illustrates the value of experimental data and monitoring in the high Andes to provide an evidence base to support soil and water conservation and management.